Camilla CERUTTI
Camilla CERUTTI
All of our dreams can come true
if we have the courage to pursue them
WD
All of our dreams can come true
if we have the courage to pursue them
WD
RESEARCH
Position
2020- PRESENT
Marie Skłodowska-Curie FELLOW
Pier Giuseppe Pelicci Lab
European Institute of Oncology
Milan, IT
PROJECT
"Single-cell epigenetic and molecular signatures in human breast cancer metastasis formation"
FUNDING
iCARE-2 Fellowship
co-funded by:
- AIRC Italian association for cancer research
- the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement
Previous research experiences
RhoGTPases in
breast and prostate cancer cell: endothelial cells in metastasis
2018
Visiting Fellow
(development fund)Fabrication of 3D perfusable microvessels
RhoGTPases in
cancer migration
2003
UNDERGRAD Research STUDENTTempia Foundation, Biella, Italy
Microarray analysis of patient-derived cells from prostatic carcinoma.
_______________________
_______________________
_______________________
_______________________
_______________________
_______________________
FUNDING
LaB!
PUBLICATIONS
Papers, Reviews, Protocols, Book Chapters my ORCiD 0000-0001-9426-686X
2021
On-chip perivascular niche supporting stemness of
patient-derived glioma cells in a serum-free, flowable culture.
Original article
Magda Gerigk , Harry Bulstrode, HaoTian Harvey Shi , Felix Tönisen , Camilla Cerutti , Gillian Morrison , David Rowitch , Yan Yan Shery Huang
LabChip 2021
2021
Analyzing the Roles of Rho GTPases in Cancer Cell Adhesion
to Endothelial Cells Under Flow Conditions
Book chapter
2019
Aspirin blocks formation of metastatic intravascular niches
by inhibiting platelet-derived COX-1/thromboxane A2
Original article
Serena Lucotti, Camilla Cerutti, Magali Soyer, Ana M. Gil-Bernabé, Ana L. Gomes, Philip D. Allen, Sean Smart,Bostjan Markelc, Karla Watson, Paul C. Armstrong,Jane A. Mitchell, Timothy D. Warner, Anne J. Ridley, and Ruth J. Muschel
J. Clin Invest 2019
2017
Endothelial cell-cell adhesion and signalling
Review
2017
MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion
to human brain endothelium
Original article
Camilla Cerutti, Laura J. Edwards, Helga E. de Vries, Basil Sharrack, David K. Male, Ignacio A. Romero.
Scientific Reports 2017
2016
MicroRNA-155 contributes to shear-resistant leukocyte adhesion
to human brain endothelium in vitro
Original article
Cerutti C, Soblechero-Martin P, Wu D, Lopez-Ramirez MA, de Vries H, Sharrack B, Male DK, Romero IA.
Fluids and Barrier of the CNS 2016
2016
MicroRNAs in Brain Endothelium and Inflammation
Book chapter | The Blood Brain Barrier and Inflammation | Springer 2016
2015
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.
Original article
Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA.
J Cereb Blood Flow Metab. 2015
2015
Zinc-imidazolate polymers (ZIPs) as
a potential carrier to brain capillary endothelial cells.
Original article
M. Chiacchia, C. Cerutti, R. Gromnicova, K. Rietdorf, I. A. Romero and D. Bradshaw
J. Mater. Chem. B, 2015
Part of themed collection: 2015 Journal of Materials Chemistry B Hot Paper
cover:http://pubs.rsc.org/en/content/articlelanding/2015/tb/c5tb90165k/unauth#!divAbstract
2015
Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer
ACKNOWLEDGED for the animal colony MMTV-neu:CB2-/- generation
J Natl Cancer Inst. 2015
2010
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.
Original article
Caffarel MM, Andradas C, Mira E, Pérez-Gómez E, Cerutti C, Moreno-Bueno G, Flores JM, García-Real I, Palacios J, Mañes S, Guzmán M, Sánchez C.
Mol. Cancer 2010
2008
JunD is involved in the antiproliferative effect of
Delta9-tetrahydrocannabinol on human breast cancer cells.
Original article
Caffarel MM, Moreno-Bueno G, Cerutti C, Palacios J, Guzman M, Mechta-Grigoriou F, Sanchez C.
Oncogene 2008
COLLABORAtions
Dr Serena Lucotti
Oxford University,UK
Cornell, NY,USA
Prof Ruth Muschel Lab
Prof Nacho Romero
The Open University UK
Dr Mauro Chiacchia
Uni of Southampton UK
Prof Darren Bradshaw Lab Functional Materials, Functional Inorganic, Materials and Supramolecular Chemistry
Dr Alessandra Granata
Cambridge University UK
Dr Andrea Serio
Crick Institute-KCL UK
Dr Gaia Spinetti
Multimedica IT
Dr Marco Rasponi
PoliMI IT
SCIENTIFIC EVENTS
CONFERENCES and MEETINGS
2020/21
III ANNUAL CONGRESS LIQUID BIOPSY ISLB 22.10.21
The 3rd Crick International Cancer Conference ONLINE 4-5.10.21
https://www.crick.ac.uk/whats-on/3rd-crick-international-cancer-conference
Alliance against cancer 6th annual meeting ON LINE
`New technologies and strategies to fight cancer`24-25.9.21Cell la vie! ONLINE edition 23.9.21
https://www.atoutcom.com/cell-la-vie-online/wp-content/uploads/sites/115/2021/09/PROGRAM.pdf
Discussion forum on model of metastasis 15.9.21The fourth Single Cell Proteomics Conference (SCP2021) ON LINE 16-18.8.21CRC6613 "Vascular Control of Organ Function"
International Meeting, ON LINE 28-30.6.21www.sfb1366.de/international-meeting
EUROPEAN RESEARCH&INNOVATION days
Let`s shape the future together 23.6.21
Organ-on-a-Chip Symposium
13.10.21
15.9.21
19.5.21
21.4.21
10.3.21
11.11.20
www.cpm.qmul.ac.uk/events/4617/organ-on-a-chip-symposium
Organ-on-a-chip: current gaps and future directions ON DEMAND 06.2020
Engineering Advanced 3D (in vitro) Models for Solid Cancer Studies 20.7.21
CELL MIGRATION seminars
Since May 2020 we have been running a once-a-week one hour seminar on the topic of cell migration featuring the latest work from group leaders, postdocs and PhD students from around the world.
EVBO Seminar Series www.evbo.org
www.evbo.org/evbo-webinar-series
Since May 2020 we have been running a twice-a-month one hour seminar on the topic of vascular biology featuring the latest work from group leaders, postdocs and PhD students from around the world.
2019
INVITED TALK Cancer Network Show&Tell
Translational pathway and cancer metastasis
Southmead Hospital, Bristol 5.2.2019
INVITED TALK Research day away Bristol Zoo 14.1.2019
Actin 2019 13.12.19
POSTER Cdc42 targets in regulating cancer cell: endothelial cell interaction
The 9th Annual UK & Ireland Early Career Blood Brain Barrier Symposium 22.11.19
TALK Cancer cell: brain endothelial cell interaction in tumor progressionBristol endothelial meeting 2019 19.9.19
TALK Cell:endothelial cell in cancer progression.
Physiological Oxygen & Metallomics Facility Workshop, King's College London London 25.9.19
Invited speaker at KCL cardiovascular division 2.8.19
London Vascular Biology Meeting, 17.7.19
QMUL -London-
Invited speaker at University of Birmingham, 3.7.19
UK cell adhesion meeting a day in the life of cellular interactions Birmingham UK. 1-2. 7.19
TALK Cdc42 targets regulate cancer cell:endothelial cell interaction in tumor progressionStress&Inflammation In Tumor Progression &Metastasis Weizmann Institute of Science, Israel 13-16.5.19
Cdc42 targets in regulating cancer cell: endothelial cell interaction
POSTER (Travel grant award University of Bristol)
CANCER IMMUNOLOGY SCIENTIFIC SYMPOSIUM FOR WORLD IMMUNOLOGY DAY 2019 Crick, London UK 26.4.19
2018-2017
Actin 2018. The Watershed, Bristol UK 14.12.18
Cdc42-targets in regulating cancer cell:endothelial cell interaction.TALK
UK Cell Adhesion Society Meeting UCL, UK
20-21.9.18
Cell adhesion in the regulation of cell behaviour
Actin 2017. The Watershed, Bristol UK 15.12.17
Cdc42-targets in regulating cancer cell:endothelial cell interaction POSTER
UK Cell Adhesion Society Meeting in association with The British Microcirculation Society (BMS) Birmingham, UK. The Many Facets of Vascular Inflammation 3-4.4.17
Roles of Cdc42 targets in regulating cancer cell:brain endothelial cell interaction (Travel grant award UKCAS) POSTER
Mechanobiology at the Shard London UK 6.2.2017
2016-2015
Actin 2016. The Watershed, Bristol UK 16.12.16
Camilla Cerutti, Nicolas Reymond, Ignacio A. Romero, Anne Ridley. Roles of Cdc42 targets in regulating cancer cell:endothelial cell interaction POSTER
Vascular Endothelium: Role in disease pathogenesis and as a therapeutic target, Imperial College London Sumposium-London-1.12.16
Roles of CDC42 targets in regulating cancer cell:endothelial cell interaction TALK
Joint Franco-Italian-Swiss, Lyon, France.
24-26 10.16
Multinational meeting on Blood-brain Interfaces
Camilla Cerutti, Nicolas Reymond, Ignacio A. Romero, Anne Ridley. Roles of Cdc42 targets in regulating cancer cell:brain endothelial cell interaction POSTER
UK Cell Adhesion Society Meeting, UCL London 22.09.16
The Force is awake integrins and beyond.
Camilla Cerutti, Nicolas Reymond, Ignacio A. Romero, Anne Ridley. Roles of Cdc42 targets in regulating cancer cell:endothelial cell interaction POSTER
Blood-brain barrier consortium club symposium,
‘The Immune System and the Blood-Brain Barrier with implications for CNS pathology’, Gordon museum,KCL London 15.4.2016
2015-2012
48th London Vascular Biology meeting King`s College London UK 9.12.15
Camilla Cerutti, Nicolas Reymond, Ignacio A. Romero, Anne Ridley. Roles of Cdc42 targets in regulating cancer cell:endothelial cell interaction POSTER
London Vascular Biology Forum Meeting, KCL-London- 12.15
Actin 2015 The Watershed, Bristol UK 27.11.15
Camilla Cerutti, Nicolas Reymond, Ignacio A. Romero, Anne Ridley. Roles of Cdc42 targets in regulating cancer cell:endothelial cell interaction POSTER
London Vascular Biology Forum Meeting, The Rayne Institute, UCL -London- 12.10.15
Barcelona Bio Med Conference Blood Brain Barrier, Barcelona, Spain. 2-4 November 2015
4th UK&Ireland Early Career Blood-Brain Barrier Symposium, UCL, London, UK BBB Symposium. 21.11.14
Actin 2014. The Watershed, Bristol UK 28.10.14
International Conference on Metal-Organic Frameworks and Open Framework Compounds (MOF2014) Kobe, Japan, Oct 2014
Chiacchia, M.; Cerutti, C.; Gromnicova, R.; Rietdorf, K.: I. A. Romero, I. A.; Bradshaw, D.
Amorphous Metal-Organic Framework as intracellular delivery vehicles to the Brain TALK
Joint Franco-Belgian-British multinational meeting on blood-brain interfaces. Universite d`Artois, Arras, France, May 2013.
C. Cerutti, Basil Sharrack, David K. Male and Ignacio A. Romero.
MiR-126 and miR-126*: two new players in flow-based leukocyte adhesion on cytokine-activated human brain endothelium in vitro. TALK
2012-2011
11th International Congress of Neuroimmunology (ISNI) Boston (MA), USA,
C. Cerutti, M.A. Lopez-Ramirez, Mark C. Hirst, Basil Sharrack, David K. Male and Ignacio A. Romero.
MiR-126 and miR-126* play a role in flow-based leukocyte adhesion on cytokine-activated human brain microvascular endothelium in vitro November 2012.POSTER
MicroRNAs & Single Molecule Biology Europe - 2012 Symposium. University of Cambridge, Cambridge, UK, November 2012.
C. Cerutti, M.A. Lopez-Ramirez, Mark C. Hirst, Basil Sharrack, David K. Male and Ignacio A. Romero.
MiR-126 and miR-126* play a role in flow-based leukocyte adhesion on cytokine-activated human brain microvascular endothelium in vitro POSTER
2nd UK&Ireland Early Career Blood-Brain Barrier Symposium, University of Liverpool, Liverpool, UK, November 2012.
C. Cerutti, Basil Sharrack, David K. Male and Ignacio A. Romero.
MiR-126 and miR-126* play a role in flow-based leukocyte adhesion on cytokine-activated human brain microvascular endothelium in vitro TALK
RNA control mechanisms in development and stress. Charles Darwin House, London, UK, November 2011.
C. Cerutti, M.A. Lopez-Ramirez, sil Sharrack, David K. Male and Ignacio A. Romero.
MicroRNA regulation of leukocyte adhesion to cultured human brain endothelial cells POSTER
1st UK&Ireland Early Career Blood-Brain Barrier Symposium, The Open University, Milton Keynes, UK November 2011.
C. Cerutti, Basil Sharrack, David K. Male and Ignacio A. Romero.
MiR-126 and miR-126* play a role in flow-based leukocyte adhesion on cytokine-activated human brain microvascular endothelium in vitro TALK
14th symposium on signal transduction in the blood brain barriers, Celal Aga Konagi Hotel, Istanbul, September 2011.
C. Cerutti, M.A. Lopez-Ramirez, Mark C. Hirst, Basil Sharrack, David K. Male and Ignacio A. Romero.
MicroRNA regulation of leukocyte adhesion to cultured human brain endothelial cells POSTER
9th International Conference on Cerebral Vascular Biology, Pieterskerk, Leiden, the Netherlands, June 2011.
C. Cerutti, M.A. Lopez-Ramirez, Mark C. Hirst, Basil Sharrack, David K. Male and Ignacio A. Romero. MicroRNA regulation of leukocyte adhesion to cultured human brain endothelial cells. POSTER
Blood-brain barrier consortium club symposium,
‘Blood-brain barrier in neurological disorders’, Gordon museum, KCL London 8.4.2011
2010-2007
10th International Congress of Neuroimmunology, Sitges (Barcelona, Spain) October 2010.
M.A. Lopez-Ramirez, C. Cerutti, B. Sharrack, M.C. Hirst, D.K. Male, I.A. Romero.
microRNAs: Key Modulators of the brain endothelial inflammatory response?
Postgraduate annual meeting of Life Sciences. The Open University, Milton Keynes, UK 13 May 2010.
C. Cerutti, M.A. Lopez-Ramirez, Basil Sharrack, David K. Male and Ignacio A. Romero.
An in vitro human blood-brain barrier model to study the role of microRNAs in leukocyte adhesion to inflamed endothelium TALK
9th Annual Meeting of the Spanish Society for Cannabinoid Research, Córdoba, Spain, 2008.
M.M. Caffarel, C. Andradas, E. Mira, C. Cerutti, S. Mañes, M. Guzmán & C. Sánchez.
Antitumoral effect of cannabinoids in a genetic model of breast cancer.
EACR20 (20th Meeting of the European Association for Cancer Research), Lyon, France, 2008.
M. M. Caffarel, C. Andradas, E. Mira, C. Cerutti, S. Mañes, M. Guzmán & C. Sánchez. Antitumoural effect of cannabinoids in an animal model of breast cancer.
ECCO 14 (The European Cancer Conference), Barcelona, Spain, 2007.
M. M. Caffarel, G. Moreno-Bueno, C. Cerutti, J. Palacios, M. Guzmán, F. Mechta-Grigoriou & C. Sánchez. Involvement of AP-1 in cannabinoid antiproliferative action.
Annual meeting of Chemistry, Biochemistry and Molecular Biology departments. School of Biology, Complutense University, Madrid, Spain, June 2007.
C. Cerutti, M. M. Caffarel , M. Guzmán & C. Sánchez.
New “in vivo” models to study the antitumoural potential of cannabinoids.
Education
BSc MSc PhD
2014 __PhD in
Neuro Vascular Immunology
Dec 2009-Feb 2014 The Open University, UK
Thesis: Role of endothelial microRNAs in leukocyte adhesion to human brain microvascular endothelium
2009__ MSc in
Industrial Biotechnology _ Pharmacogenomic
Dec 2005-April 2009 University of Milano-Bicocca , IT
Thesis: Cannabinoids in breast cancer in vitro and in vivo
2005__ BSc in
Biotechnology _ Medical
Oct 2000-Dec 2005 University of Milano-Bicocca, IT
Thesis: Study of patients-derived prostatic cancer cells gene expression by microarray
Sept 1995-July 2000 Science high school A. Avogadro Biella, IT
SUBJECTS: Biology, Chemistry, Earth science, Math, Physic, Informatic, Geography, History, Philosophy, artistic design, Art history, technical design, Latin, English, Italian literature
PhD graduation day
MSc graduation day
BSc graduation day
PROFESSIONAL CONTRIBUTION and AFFILIATIONS
REVIEWER
2019-present Reviewer
2019-present Reviewer for The Journal of Thrombosis and Haemostasis
2020-present
Reviewer for Molecular Biology Reports
2021-present
Reviewer for iSCIENCE
2021-present
Reviewer for the Journal of cellular and molecular medicine
2022-present
Reviewer for CNS Neuroscience & Therapeutics
SOCIETY Memberships
2019-present
European vascular biology association EVB
OUTREACH-COMMUNITY ENGAGEMENT
Public engagement
2021-2022 Fondazione AIRC- incontro con la ricerca
www.scuola.airc.it
Public engagement with:
2021: high school students of ’Istituto Superiore Einaudi` in Cremona (IT) to present what is cancer, my cancer research project and the life of a scientist.
2022: high school students of Istituto M. Bossi in Seregno (MB) to present what is cancer, my cancer research project and the life of a scientist.
- 2019 Soapbox Science
www.soapboxscience.org , Bristol, UK
Public outreach platform for promoting women scientists and the science they do.
Speaker Dr Camilla Cerutti (@ccamilla81)“Location, location, location: when CANCER spread and relocate,
we’ve got a deadly problem-METASTASIS!”
- 2019 Big Bang
Public engagement, Weston Super Mare UK
Public engagement on human cells and diseases studied at Bristol University.
- 2018 United learning
www.unitedlearning.org.uk Walthamstow Academy London, UK
Outreach with pupils `Scholars’ Club talk for University
- 2017 Scientist&Co
www.scientistsandco.org London, UK
Roles: SHADOW a SCIENTIST in the lab, CV clinic and mock interview for academia.
- 2017 SHADOW a SCIENTIST
www.scientistsandco.org London, UK
Outreach with pupils* from disadvantaged background
*Disclosure and Barring Service DBS check by the King’s Widening Participation team for working with children and a safeguarding training course were undertaked for these activities of outreach with pupils
- 2017 CV clinic
www.scientistsandco.org London, UK
Outreach with pupils* from disadvantaged background
- 2016 and 2017 King`s STARS
Science Training for Aspiring Research Scientists,
King`s College London, UK
Role: Hosting as lab demonstration in biochemistry techniques, a group of year 12 science students* from schools that have a poor record of student progression to Universities.
- 2017 Science Gallery
www.london.sciencegallery.com ideas on how to explain science with art to young
*Disclosure and Barring Service DBS check by the King’s Widening Participation team for working with children and a safeguarding training course were undertaked for these activities of outreach with pupils
COMMITTEE LEADERSHIP
2020
School of molecular medicine (CMM)
ORGANIZER `RESEARCH DAY AWAY` SOCIAL ACTIVITIES
2019
CMM research day way,
CHAIR for the cancer session
HOBBIES
- Yoga
- Snowboarding
- Mountain hiking
- Basketball TEAMS: La Senavra basket ,Tumminelli Romana Basket. Milan, Italy
- Figure Ice skating at competitive level, Libertas Ghiaccio, trainer Bertolino Lucia. Turin, Italy
- Rhythmic gymnastic. Turin, Italy
VOLUNTEERING
2016 KCL Dental Institute, Dr Guy Carpenter Laboratory, provide samples for the Project `assessing the relationship between saliva ferning and ovulation in woman`
2006 volunteer during the XX Olympic Winter Games Turin (Italy) as Ice Skater assistant
- 1995 to 2000 summer volunteering schemes structured as daytime volunteering with elder people/disabled/children and evening time consideration and analysis of the experience with other volunteers, furthermore self managing the guest house was part of the daily tasks. Belletti Bona -BI-, Sermig -TO-, Summer camp with children -BI-
CAREER DEVELOPMENT
CAREER>>>>>>>>>>>>>>>>>>>>>>
2020/2021
- iCARE-2 training-Science Communication 9/21
- iCARE-2 training-Research Integrity 7/21
2019
- How to apply for grant application UoB 2019
- Teaching@Bristol for Research Staff: Small Group Teaching
- How to Prepare a Good Research Bid – Health Science & Life Science
- Peer to Peer Mentoring UoB 2019
- Working Towards a Lectureship or Fellowship UoB 2019
- 2018
- TRAINING in the fabrication of perfusable microvessels in Dr P Searson lab March, Johns Hopkins University USA
- -https://hub.jhu.edu/2014/10/30/close-up-look-at-metastasis/
- - https://www.youtube.com/watch?v=SuV4uY45ZCQ
- -http://cancerres.aacrjournals.org/content/canres/74/17/4937/F1.large.jpg
- -https://www.ncbi.nlm.nih.gov/pubmed/24970480
- - https://www.youtube.com/watch?time_continue=86&v=IumJxRCqgw8
- 2017
- DEPArray workshop June 2017 Cancer Centre Guys London
- Nikon Microscopy workshop KCL
- ZEISS Life Science Imaging Workshop
- Advancing innovation in health KCL
- Innovation forum towards a sustainable future w Martin Crouch,Adrian Haworth, IanRogers ICL
- Adobe Illustrator Level I QA
- KCL SUSTAINABILITY :
- Workshop #4 - PROCUREMENT
- Workshop #3 - BEHAVIOR CHANGE
- Workshop #2 - WASTE
DEVELOPMENT
2016 _KCL LONDON_
- KCL SUSTAINABILITY Workshop #1 - ENERGY
- The Strategic Academic course with Dr Shelda Debowski
- Academia vs industry workshop
- Career development event&workshops
- Leadership essentials with Dr Steve Hutchinson 3dd
- Diversity in Leadeship Panel Discussion Chaired by Prof Catherine Williamson with Liz Brutus, Mercy Jeyasingham, Sylvia Court, and Nandita Quaderi
- Mentoring in the workplace workshop
- Career day Cancer Studies and Randall Centre
- Writing research proposal with Dr Geoff Oldham
- Applying for associate fellow in higher education
- Research grant: maximize your success
- 2016 NC3Rs. Workshop: Using microsampling to refine blood sampling procedures in industry and academia
2015
- Teaching in Higher education course &application KCL
2012-14
- Introduction to the news media,BBCLondon
- Irene Joliot-Curie Conference 2013: Establishing an independent career ICL London
- Getting published in journals MK
OTHER MEETINGS
60 years of immunology celebration of The British Society for Immmunology Royal Society London Oct 2016
Professor Stefan Hell, joint nobel prize for Chemistry in 2014, Optical microscopy: the resolution revolution part of King`s International Lecture dedicated to Rosalind Franklin -KCL- 6.4.16
Athena SWAN Networking Lunch and Lecture with Laurie H. Glimcher, as part of the King`s International Lecture dedicated to Rosalind Franklin Guy's Hospital and KCL NHH, London 28.9.15
Institute of Biomedical and Biomolecular Science seminar: ‘Changes in the perivascular drainage pathways associated with ageing, hypertension and possession of ApoE4. Significance of the pathogenesis of Alzheimer’s disease’ by Prof Roxana Carare, University of Portsmouth, Portsmouth 7.5.14
London Barts and The London school of medicine and dentistry seminar:
‘The Brain Barriers: check Point Charlie for the immune cell entry into the CNS’ by Prof Britta Engelhardt, London 6.6.13
